AMBULATORY BLOOD PRESSURE IN RELATION TO PLASMA AND URINARY MANGANESE

Objective: The association of blood pressure (BP) with manganese, an essential trace element required for human health, remains poorly studied. Design and method: In 734 randomly recruited Swiss participants (mean age, 47.5 years; 51.4% women), we related ambulatory BP to two biomarkers, plasma manganese (pMn) the urinary excretion (uMn). To allow diurnal variation, assessed uMn over 24 h during wakefulness sleep, using split urine samples. Results: h, day- night-time systolic/diastolic BPs averaged 119.8/78.1, 123.8/81.2 107.0/68.3 mm Hg; corresponding medians were 199.5, 83.0, 51.5 umol median pMn 0.52 ug/L. analyses dichotomized by greater was associated higher (+4.1/+ 2.3 P<= 0.0003), daytime lower (3.5/ 1.9 0.0067) nighttime (+2.9/+ 1.2 0.046). multivariable-adjusted analyses, significance (P<= 0.030) retained positive diastolic systolic in relation at night. sizes a twofold increment biomarkers amounting 0.77 Hg (95% confidence interval [CI], 0.08–1.47 Hg), 0.97 (CI, 0.20–1.76) 1.33 0.20–2.50 respectively. Conclusions: conclusion, there associations between